Manasseh filled Jerusalem with the blood of the innocent; in context, the blood appears to be the blood of prophets (2 Ki 21:10-16). This is one of the continuing charges against Manasseh after Josiah’s reign is over (24:3-4). The blood of the prophets (or, at least, of the innocent) calls up the blood avenger who comes to destroy the city.
The pattern is the same in Revelation: The blood of the saints is poured out on the city, and as a result the Lord brings vengeance against the harlot who is drunk with the blood of saints.
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