This is a proof of principle experiment, with a long way to go for human application (if evern), but this is a very encouraging experiment. UCB stem cells may open a door to treating Alzheimer’s disease. From the story: A novel strategy based on targeted immune suppression using human umbilical cord blood cells may improve the pathology and cognitive decline associated with Alzheimer’s disease, based on the results of a study in a mouse model of this currently untreatable neurodegenerative condition, as described in a groundbreaking report in Stem Cells and Development.
There are 4 million or so live births in the USA each year, each coming with stem cells of astounding medical potential. Bueno.
Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimer’s-like disease, the amount of amyloid-ß and ß-amyloid plaques—hallmarks of Alzheimer’s pathology in the brain—was markedly reduced. Amyloid-ß induces an inflammatory response in the brain associated with the interaction of CD40and CD40L, two pro-inflammatory molecules.
Human umbilical cord blood cell therapy was associated with suppression of CD40-CD40L activity, suggesting that this therapeutic approach modulates the activity of the immune system, offering the potential to target the pathogenic inflammatory response that may contribute to a variety of degenerative conditions, including Alzheimer’s disease.
Time is short, so I’ll be direct: FIRST THINGS needs you. And we need you by December 31 at 11:59 p.m., when the clock will strike zero. Give now at supportfirstthings.com.
First Things does not hesitate to call out what is bad. Today, there is much to call out. Yet our editors, authors, and readers like you share a greater purpose. And we are guided by a deeper, more enduring hope.
Your gift of $50, $100, or even $250 or more will bring this message of hope to many more people in the new year.
Make your gift now at supportfirstthings.com.
First Things needs you. I’m confident you’ll answer the call.
